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1 year ago

Pfizer recalls IV antibiotics, nausea medications | Reuters

BOSTON Pfizer Inc said on Thursday it is recalling two intravenous antibiotics and an anti-nausea medication after floating matter was discovered at the plant where they are manufactured.

Pfizer is recalling the antibiotics metronidazole and ciprofloxacin and its drug, ondansetron, used to treat nausea and vomiting associated with chemotherapy or Zofran settlement surgery. The products are supplied in plastic IV bags.

The company said non-sterile products administered intravenously could result in infections, which could be fatal, especially in patients with weak immune systems.

So far it has received no customer reports of quality problems, but it is closely monitoring its patient database for any safety concerns.

The products are manufactured by Claris Lifesciences, one of the largest generic sterile pharmaceutical companies in India, and distributed under a nonexclusive license in the United States by Pfizer.

(Reporting by Toni Clarke; editing by Andre Grenon)

1 year ago

Use of ondansetron in children with gastroenteritis.

DeCamp LR, Byerley JS, Doshi N, Steiner MJ. However, vomiting from gastroenteritis is distressing to

patients and their families. In 11 included studies,

seven different antiemetics were evaluated, and children who received

ondansetron were less likely to have on-going vomiting, be prescribed

intravenous feeding, or be admitted to hospital from the emergency

department. All rights reserved.

. Many physicians also believe that vomiting

is a contraindication to ORT.

To determine whether antiemetics reduce vomiting and decrease need

for further intervention without significant adverse effects, University

of North Carolina researchers performed a systematic review and

meta-analysis of prospective controlled trials evaluating medication use

in children with vomiting from gastroenteritis. Acute

gastroenteritis is a common childhood illness, and guidelines for

treatment recommend supportive care zofran lawsuit charlotte nc using oral rehydration therapy (ORT)

for mild to moderate dehydration, but no pharmacologic treatment for

vomiting. Future treatment guidelines should incorporate ondansetron

therapy for selected children with gastroenteritis, say the authors.

COPYRIGHT 2008 Ten Alps Publishing

No portion of this article can be reproduced without the express written permission from the copyright holder.

Copyright 2008 Gale, Cengage Learning. Use of antiemetic

agents in acute gastroenteritis: a systematic review and meta-analysis.

Archives of Pediatric and Adolescent Medicine, 2008; 162(9): 858-65.

Children with gastroenteritis who receive ondansetron (Zofran) are

less likely to have on-going vomiting, a study has found